Structural diversity and biological activity
Structural diversity and biological activities of cages Garcinia xanthones: recent updates
Announcing a new publication of review articles for Acta Materia Medica newspaper. Caged xanthones are a class of naturally occurring compounds with approximately 200 members that are commonly isolated from the Garcinia genus of the family Clusiaceae (formerly Guttiferae). They are often characterized by a notable 4-oxatricyclo[ 4.3.1.03,7]dec-2-one (caged) architecture with a common xanthone backbone. Because most caged xanthones have potent anticancer properties, they have become a target of interest in natural product chemistry. The unique chemical architectures and increasingly recognized biological significance of these compounds have stimulated numerous studies and intense interest in their isolation, biological evaluation, and mechanistic studies.
The authors of this article summarize recent advances and developments in the chemistry and biological activity of caged animals. Garcinia xanthones and several compounds of non-Garcinia origin, from the years 2008 to 2021, offering an in-depth discussion of their structural diversity and medicinal potential. A preliminary discussion of structure-activity relationships is also provided.
Article reference: Yee Lin Phang, Changwu Zheng and Hongxi Xu. Structural diversity and biological activities of caged Garcinia xanthones: recent updates. Acta Materia Medica. Flight. 1(1):72-95. DOI: 10.15212/AMM-2022-0001
Key words: caged xanthone, gambogenic acid, isomorelline, neobractatin, anticancer, structure-activity relationship
# # # # # #
Acta Materia Medica welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles, and study protocols.
Submissions at Acta Materia Medica are made using ScholarOne, the online submission and peer review system. Registration and access are available at https://mc04.manuscriptcentral.com/ammed
Questions about the journal can be sent to [email protected]
Please visit https://amm-journal.org/ to learn more about the journal.
Editorial Board: https://amm-journal.org/index.php/editorial-board/
There are no author submission or article processing fees.
# # # # # #
Warning: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.